Skip to main content

GlucoVantage®The Super Berberine™ The first commercially available brand of Dihydroberberine (DHB), a derivative of berberine.


DHB

DHB is a metabolite of berberine. Interestingly, gut microbes reduce berberine into its tissue-ready form of DHB, which is then converted back to berberine after absorption in intestinal tissues. In other words, supplementation with DHB bypasses the rate-limiting step of microbial reduction. This is why DHB has significantly greater functional benefits compared to berberine. Supplementation with DHB mitigates potential GI distress that some experience with berberine, which is likely the result of poor absorption and/or microbial reduction. New research is being conducted with DHB having potential synergy when co-administered with Bifidobacterium species enhancing the probiotic (as opposed to dysbiotic) nature of the gut.

Superior Bioavailability

Its well-documented benefits notwithstanding, berberine is limited by poor bioavailability. Research has shown that DHB displays significantly improved absorption and enhanced bioavailability relative to berberine. Animal data shows a 5-fold relative increase in the absorption rate (DHB > berberine).[1] Furthermore, the transdermal application of DHB may be very effective, as a topical application in animal models has led to 7-fold higher bioavailability compared to oral berberine.[2]

Reducing Fat and Improving Glucose Tolerance

DHB can reduce adiposity and improve glucose tolerance in mice fed a high-fat diet. To achieve similar effects, berberine needed to be administered at a dose almost 4 times that of DHB[3]

Improving Insulin Sensitivity

DHB has been shown to display markedly improved in vivo efficacy (compared to berberine) in terms of counteracting adiposity, tissue fat gain and insulin resistance in rodents via increased AMPK activity, which also improves insulin sensitivity. These enhanced effects are likely due to enhanced oral bioavailability.[3]

Regulating Lipid Metabolism Balance

One of the most important strategies to maintain lipid metabolism balance and control body mass is to develop inhibitors of pancreatic lipase (PL).[4] On the molecular level, DHB can better combine PL to produce inhibition. In an in vitro activity bioassay, DHB shows a stronger inhibitory effect than that of berberine. (IC50: concentration of natural alkaloids that could inhibit PL activity by 50 %)

References

[1] Feng R., Shou J. W., et al. Scientific Reports, 5:12155. [2] Buchanan B et al., PLOS One 2018 March; 13(3): e0194979. [3] Turner N., Li J. Y., Gosby A., et al. Diabetes, 2008,

57(5):1414-1418. [4] Mohammad M., Al-Masri I. M., Issa A., et al. Medicinal Chemistry Research, 2013, 22(5):2273-2278.


Labels:

Comments

Post a Comment

Please do not enter any spam link in the comments box.

Popular posts from this blog

GlucoVantage® , Shawn wells NNB Nutrition Chief Science Officer

NNB Nutrition’s GlucoVantage® is the first commercially available brand of Dihydroberberine . Which is an active metabolite of Berberine dietary supplement ingredients shown to optimize blood sugar levels, & improve insulin sensitivity and body composition GlucoVantage® solves Berberine major imitations of low bioavailability, GI distress, and the need for frequent dosing: This means with GlucoVantage® you can consume more carbohydrates with fewer negative impacts assisting both dieters and those looking to “Clean bulk” GlucoVantage® is typically used in weight loss formulas blood sugar optimization supplement such as GlucoVantage® glucose disposal agents, ketogenic products, as well as gut health and anti-aging supplements. Unlike Berberine large doses, GlucoVantage® can be taken one to two times per day at doses of 100 to 200mg per serving and is typically taken before a carbohydrate-containing meal, getting the body toward muscle instead of fat.
Post a Comment
Read more

A pure safe formula. Dihydroberberine (DHB)

ALWAYS CHOOSE HIGHEST QUALITY INGREDIENTS –. Don't put other nasty ingredients into your body. Our GlucoVantage® is GMO-free, soy-free, gluten-free and has no preservatives, stearates, silicone dioxide or artificial ingredients. A pure safe formula. Dihydroberberine (DHB), a derivative of Berberine, which is an alkaloid isolated from Berberis Aristata. Our formula is made up of only pure DHB with no harmful additives. NNB NUTRITION
Post a Comment
Read more

Berberine VS Dihydroberberine

The Truth of the Effectiveness of the Berberine   Berberine is an alkaloid extracted from various plants. It's primarily used to reduce insulin resistance. [1] Berberine can activate AMPK [2] while inhibiting PTP1B [3] , thus increasing insulin sensitivity. Berberine products are gaining popularity among consumers who want to support healthy blood glucose management. However, the feedback from different consumers varies considerably. Based on our research of consumer feedbacks on multiple brands, almost half reported that Berberine does not work when it comes to controlling blood glucose levels. Even worse, some consumers reported adverse events, such as GI issues like constipation. [4, 5]   Figure 1: Customer Feedbacks for Berberine product   If companies are using good material and recommending the right dosage, why do their products sometimes not work? The answer is gut microbiota.   In the human intestine, there are two pathways for Berberine to get into blood and be absorbed
Post a Comment
Read more